A leading reason touted as evidence the moon landing was fake is that we can't see the stuff supposedly left on the moon. Once you start going into angular resolution and the physics of optics you've already lost the argument.
Sure, but you'll never win. So whether you want to call it "lose" the argument or just apply "lose" to the amount of time and/or your own sanity, it's still a loss. You will definitely not be changing the other party's mind.
